Original Article

Metabolic Liver Diseases

Bidirectional Regulation between Metabolic Dysfunction-associated Steatotic Liver Disease and Sarcopenia via Liver-muscle Crosstalk Yeyu Song, Yameng Liu, Jie Jiang, Youjie Zheng, Zixuan Wang, Cen Xie, Jian-Gao Fan Published online: January 7, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00538

Metabolic Risk Factors and Clinical Presentations of Metabolic Dysfunction-associated Steatotic Liver Disease Using Data from the All of Us Research Program Ke-Qin Hu, Seyedeh Neelufar Payrovnaziri, Argyrios Ziogas, Steven Hiek, Kuangda Shan, Tevan Luong, Jenny Fang, Hoda Anton-Culver Published online: January 27, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00393

Infectious Hepatitis

Eight-year Results from Two Randomized Phase 3 Trials of Tenofovir Alafenamide for Chronic Hepatitis B Virus Infection in China Jinlin Hou, Qin Ning, Zhongping Duan, Yu Chen, Qing Xie, Lunli Zhang, Shanming Wu, Hong Tang, Jun Li, Feng Lin, Yongfeng Yang, Guozhong Gong, Yanwen Luo, Yan Chen, Frida Abramov, Leland J. Yee, Hongyuan Wang, Roberto Mateo, Tahmineh Yazdi, Irina Botros, Chengwei Chen, Yan Huang, Mingxiang Zhang, Jidong Jia Published online: February 4, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00438

Traditional and Novel Virologic Markers for Functional Cure and HBeAg Loss with Pegylated Interferon in Chronic Hepatitis B: A Systematic Review and Meta-analysis Ying Zhang, Long-Fei Wang, Jing Chen, Mindie H. Nguyen, Qi Zheng Published online: December 26, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00443

Hepatic and Biliary Neoplasia

Prognostic Nutritional Index Predicts Outcomes in Hepatocellular Carcinoma Treated with Atezolizumab and Bevacizumab: A Propensity Score-matched Analysis Yuan-Hung Kuo, Wei Teng, Yen-Hao Chen, Po-Ting Lin, Tsung-Han Wu, Chung-Wei Su, Wei-Ting Chen, Chen-Chun Lin, Chao-Hung Hung, Sheng-Nan Lu, Shi-Ming Lin, Jing-Houng Wang, Chun-Yen Lin Published online: December 8, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00418

Liver Transplantation and Surgery

Serum miR-381-3p: Diagnostic Role and Mechanisms in Liver Transplant Ischemia-reperfusion Injury Xiaobin Chi, Zerun Lin, Zhijian Chen, Jianda Yu, Yongbiao Chen, Honghuan Lin, Qiucheng Cai, Lizhi Lv Published online: February 5, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00571

Liver Failure, Cirrhosis and Portal Hypertension

Cathepsin K Alleviates Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway and Inducing Hepatic Stellate Cell Apoptosis Zhandong Lin, Yue Shi, Mengjiao Sun, Jiawei Cui, Dandan Zhao, Yaoyao Mao, Congyue Zhang, Ying Zhang, Qianqian Zheng, Yukai Chen, Shaoya Li, Yuemin Nan Published online: January 22, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00592

Review Article

Tumor Vaccines in Hepatocellular Carcinoma: Advances, Challenges, and the Path Toward Precision Immunotherapy Bin Niu, Jun Xu, Liaoyun Zhang Published online: January 19, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00401

Risk Factors and Biomarkers for Immune Checkpoint Inhibitor-mediated Hepatotoxicity: Emerging Insights and Future Perspectives Zaoqin Yu, Yanjiao Xu, Wei Li, Yingjie Hu, Chengliang Zhang Published online: January 23, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00622

Repurposing SGLT2 Inhibitors for Cirrhotic Ascites: From Mechanistic Research to Clinical Exploration Yuan Gao, Yunyi Gao, Dong Ji, Zhongjie Hu Published online: January 22, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00465

Hot Topic Commentary

Immune Checkpoint Inhibitor–induced Liver Injury: A Critical Appraisal of Treatment and Rechallenge Controversies Fernando Bessone, Nelia Hernandez Published online: January 19, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00450