Original Article

Hepatocellular Carcinoma Risk Stratification for Cirrhosis Patients: Integrating Radiomics and Deep Learning Computed Tomography Signatures of the Liver and Spleen into a Clinical Model Rong Fan, Ya-Ru Shi, Lei Chen, Chuan-Xin Wang, Yun-Song Qian, Yan-Hang Gao, Chun-Ying Wang, Xiao-Tang Fan, Xiao-Long Liu, Hong-Lian Bai, Dan Zheng, Guo-Qing Jiang, Yan-Long Yu, Xie-Er Liang, Jin-Jun Chen, Wei-Fen Xie, Lu-Tao Du, Hua-Dong Yan, Yu-Jin Gao, Hao Wen, Jing-Feng Liu, Min-Feng Liang, Fei Kong, Jian Sun, Sheng-Hong Ju, Hong-Yang Wang, Jin-Lin Hou Published online: August 1, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00091

Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress Qian Zhang, Jiajun Wang, Yifan He, Kun Zhang, Wei Hong, Tao Han Published online: July 18, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00112

Biomarker Discovery for Metabolic Dysfunction-associated Steatotic Liver Disease Utilizing Mendelian Randomization, Machine Learning, and External Validation Gong Feng, Giovanni Targher, Christopher D. Byrne, Na He, Man Mi, Yi Liu, Hongbin Zhu, Ming-Hua Zheng, Feng Ye Published online: July 16, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00270

ATOX1 Promotes Hepatocellular Carcinoma Carcinogenesis via Activation of the c-Myb/PI3K/AKT Signaling Pathway Qin Ouyang, Siyu Jia, Qianyu Zhu, Yanmeng Li, Huaduan Zi, Sisi Chen, Pingping He, Hengcheng Tang, Yanling Li, Anjian Xu, Bei Zhang, Xiaomin Wang, Xiaojuan Ou, Donghu Zhou, Jian Huang Published online: July 7, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00422

Cumulative Hepatitis B Surface Antigen/Hepatitis B Virus DNA Ratio in Immune-tolerant Hepatitis B Patients: A 10-year Follow-up Study Dawu Zeng, Yanfang Huang, Sheng Lin, Naling Kang, Yanxue Lin, Jiaji Jiang, Yueyong Zhu, Qi Zheng, Jiming Zhang Published online: July 4, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00205

Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study Xiuding Zhang, Haoda Weng, Qinzhi Deng, Min Deng, Xuwei Wu, Zuxiong Huang, Shourong Liu, Rui Wu, Chunlian Ma, Yao Xu, Jianfeng Zhong, Jie Yang, Yinxia Wu, Huajiang Shen, Feng Ding, Fang Wang, Xuezhen Zhai, Chunxian Peng, Haotang Ren, Jie Jin, Xiangfei Xu, Xiaofei Li, Xiaoting Ye, Guoqing Qian, Shuilin Sun, Xuebing Yao, Haifeng Miao, Qianggu Xiao, Shaoheng Ye, Qing Zhang, Xinyi Xu, Xia Yu, Yue Yu, Yan Lan, Huilan Tu, Xianbin Xu, Xinrong Zhang, Rui Huang, Xiaohan Qian, Qiao Yang, Jifang Sheng, Yu Shi Published online: July 3, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00211

Integrated Analysis of Serum and Fecal Metabolites Reveals the Role of Bile Acid Metabolism in Drug-induced Liver Injury: Implications for Diagnostic and Prognostic Biomarkers Simiao Yu, Sici Wang, Ping Li, Haocheng Zheng, Jing Jing, Tingting He, Xia Ding, Ruilin Wang Published online: June 30, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00073

Adrenomedullin as an Immunomodulator of CD14+MerTK+ Circulating Monocytes in Liver Failure Syndromes Francesca Maria Trovato, Florent Artru, Roosey Sheth, Rima Abdalla, Joseph Wilson, Anna Broderick, John Smith, Stephen Atkinson, Mark J. McPhail Published online: June 24, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00074

Global Trends and Cross-country Inequalities of Acute Hepatitis E in the Elderly, 1990–2021: A Comprehensive Analysis Deliang Huang, Jinyan Jiang, Jinghan Peng, Zhibin Zhu, Yuanyuan Chen, Siyu Zhang, Huiyi Lai, Hong Yu, Qi Zhao, Yanna Wu, Yanping Chen, Jun Chen Published online: May 30, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00101

Review Article

Portal Vein Thrombosis in Liver Cirrhosis: A Review of Risk Factors and Predictive Indicators Zhicheng Yang, Yongle Zhao, Honglin Chen, Han Zhang, Maoting Tan, Xianliu Li, Lingling Tao, Hongyun Zhao Published online: July 29, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00124

Emerging Serum Biomarkers for Chronic Hepatitis B: Focus on Serum HBV RNA and HBcrAg Yike Tian, Haibo Yu, Juan Chen Published online: July 22, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00064

Orphan Nuclear Receptors in Metabolic Dysfunction-associated Steatotic Liver Disease Development Huan Li, Jian Chen, Ziyin Huang, Mingkai Chen Published online: June 19, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00019

Research Letter

Heterotopic Auxiliary Liver Transplantation in a Child with Portal Hypertension Using a Discarded Partial Right Liver Allograft from an Adult Patient with Alveolar Echinococcosis Chong Yang, Xinyu You, Donghui Cheng, Wenbin Cao, Tao Lu, Wenjun Jiang, Jipeng Jiang, Bangyou Zuo, Yu Zhang Published online: July 22, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00107

Development and Validation of a Novel Noninvasive Model to Predict Liver Fibrosis Staging in Untreated Patients with Chronic Hepatitis B Jianhua Hu, Xiaoli Zhang, Zhibo Zhou, Fangfang Geng, Hongyu Jia, Linfeng Jin, Weixiang Zhong, Guodong Yu, Xue Wen, Hainv Gao, Yida Yang Published online: July 7, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00175

Complete Resolution of Refractory Ascites and Pleural Effusion with Sustained Improvement in Urinary Sodium Excretion in a Cirrhotic Patient Treated with Empagliflozin Wei Qin, Yunyi Gao, Yuanyuan Zhao, Ning Bian, Weiguang Fan, Wei Wang, Yuan Gao, Zhongjie Hu Published online: June 19, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00172