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A Dual Time Window-driven Strategy to Optimize Primary Biliary Cholangitis Treatment via Alkaline Phosphatase Normalization Han Zhao, Yansheng Liu, Yingmei Tang, Ningning Wang, Yanmin Liu, Yiling Li, Chunyang Huang, Jieting Duan, Yan Feng, Linhua Zheng, Ruiqing Sun, Xiufang Wang, Juan Deng, Gui Jia, Patrick S.C. Leung, M. Eric Gershwin, Yulong Shang, Ying Han Published online: May 15, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00082

Occlusion of Paraspinal Vein Shunt Alleviated Post-TIPS Hepatic Myelopathy in a Patient with Cirrhosis Yuhong Suo, Lixue Xu, Xinyan Zhao, Yu Wang, Fuliang He, Jidong Jia Published online: May 14, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00044

Metabolic Dysfunction-associated Steatotic Liver Disease Diminishes the Efficacy of miR-125b-5p-engineered MSC Therapy for Hepatocellular Carcinoma via HK2 Upregulation: A Multimodal Theranostic Study Lishan Shen, Xiaowen Luo, Xiaorui Su, Xiang Zhou, Fengyun Zou, Shuangshuang Zhong, Yayin Deng, Boya Yin, Zhicheng Yao, Ruomi Guo Published online: May 11, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00709

Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review Nikolaos T. Pyrsopoulos, Nadege Gunn, Prasun K. Jalal, George E. Catinis Published online: May 8, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00698

Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B Siqi Sun, Sisi Yang, Yihe Yu, Jiyang Chen, Jintao Ning, Yida Yang, Hongyu Jia Published online: April 28, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00118

A Novel Simplified Prognostic Model for 90-day Transplant-free Survival in Patients with Severe Acute Liver Injury/Acute Liver Failure Yan Ren, Manman Xu, Wenling Wang, Ming Kong, Yu Chen Published online: April 28, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00075

The Association of Alpha-1 Antitrypsin Deficiency and Arterial Aneurysms: An Update and Review Moana Da Silva Santiago, George Y. Wu Published online: April 27, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00043

Bile Drainage Improves Survival in Amatoxin-induced Severe Liver Injury: A Prospective Pilot Cohort Study Xiuying Ma, Bin Han, Wei Yue, Yuan Shen, Jiawei Geng Published online: April 27, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00057

Letter to the Editor: Genotype-specific Response to 144-week Entecavir Therapy for HBeAg-positive Chronic Hepatitis B with a Particular Focus on Histological Improvement: A Prospective Study Chenhao Ye, Lei Wang Published online: April 27, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2026.00159

The Multifaceted Roles of Gut Microbiota and Their Metabolites in Metabolic Dysfunction-associated Steatotic Liver Disease: A Literature Review Yunqi Zhang, Dengqin Wang, Bo Zhuang, Fangzhuo Zhu, Chengwei Tan, Jing Zhang, Qianqian Zhang Published online: April 24, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00605

A Multi-omics Investigation Identifies TACC3 as a Driver of Immunosuppression in Intrahepatic Cholangiocarcinoma via Activation of the STAT3-PD-L1 Axis Hao Wang, Zhiquan Xu, Ziqi Zhang, Yan You, Ranning Xu, Hongli Chen, Hongshuai Cui, Xiaoyong Luo, Rui Liao Published online: April 10, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00616

Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy and Immunothrombosis in Hepatitis B Virus-related Acute-on-chronic Liver Failure Xitang Li, Suping Hai, Xizhe Zheng, Peng Hu, Wenhui Wu, Qiang Gao, Junjian Hu, Binghui Yu, Feiyang Xu, Huiling Xiang, Qin Ning, Xiaojing Wang Published online: April 10, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00666

Dubin-Johnson and Rotor Syndromes: A Review and Update of Pathophysiological Mechanisms Bianca Thakkar, George Y. Wu Published online: April 9, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00560

Unlocking the Future of Hepatocellular Carcinoma Early Diagnosis: The Promise of Extracellular Vesicle Biomarkers Kunxiang Li, Zhihua Zuo, Xinyi Ou, Miyuan Yang, Yirui Qin, Bing Zhang, Yongcan Guo Published online: April 8, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00589

Tongue Image Analysis and Clinical Data Fusion: A Novel Approach for Non-invasive Diagnosis of Metabolic Dysfunction-associated Fatty Liver Disease Chen-Xia Lu, Chuan-Xi Tian, Yi-Bo Jiao, Hui Zhu, Hai-Yan Yu, Zi-Xin Shu, Ling-Han Zhang, Jia Zhang, Lan Wang, Qi Hao, Wen-Bin Zou, Ming-Zhong Xiao, Cheng-Hai Liu, Qiu-Yang He, Bee Luan Khoo, Xiao-Dong Li Published online: April 8, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00631

m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease Nan Luo, Zhihai Xu, Dongmei Zhao, Xue Yang, Yu Tian, Rongkuan Li Published online: April 2, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00570

Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025) Wenjing Ni, Junping Shi, Jian-Gao Fan, Jie Li, Chronic Disease Management Branch of China Medical Biotechnology Association, Chinese Research Hospital Society (Integrative Chinese and Western Medicine), Chinese Society of General Practice, Chinese Medical Association, and Expert Group of Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care Published online: April 2, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00711

Pegylated Interferon-based Treatment Improves Response Rates in Immune-tolerant Patients with Chronic Hepatitis B: A Prospective Trial Min Liu, Lili Zuo, Yuting Zhang, Bing Bu, An Xiao, Ling Zhu, Xiuying Ma, Yilan Wang, Wei Yue, Jiawei Geng, Xueshan Xia Published online: March 31, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00712

Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization Xianwu Yang, Shirui Huang, Ruisi Ma, Zhihui Zhu, Yingquan Zhuo, Jiafei Yang, Jun Du, Huajian Gu Published online: March 24, 2026 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00561