Hepatosplenic Volumes and Portal Pressure Gradient Identify One-year Further Decompensation Risk Post-transjugular Intrahepatic Portosystemic Shunt Xinyu Chen, Yicheng Lin, Kefeng Jia, Rong Lv, Jiajun Tian, Fenghui Li, Jun Li, Yiwen Zhang, Ning Wang, Zhongsong Gao, Weili Yin, Fang Wang, Ping Zhu, Chao Yang, Jiayin Wang, Tao Wang, Junqing Yan, Ying Liu, Qing Ye, Huiling Xiang Published online: September 3, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00199

The Role of Hepatic SIRT1: From Metabolic Regulation to Immune Modulation and Multi-target Therapeutic Strategies Houyan Zhang, Dongjie Wu, Qingjuan Wu, Yanxuan Wu, Ziwei Guo, Li Wang, Yi Wang, Qian Zeng, Liang Shi, Bin Shi, Gongchang Yu, Wenliang Lv Published online: September 3, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00259

The Mechanisms behind Thrombocytopenia in Patients with Portal Hypertension and Chronic Liver Disease Valeria M. Fernández-Garibay, Mariana M. Ramírez-Mejia, Guadalupe Ponciano-Rodriguez, Ran Wang, Xingshun Qi, Nahum Méndez-Sánchez Published online: September 3, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00279

Mapping Metabolic Dysfunction-associated Steatotic Liver Disease Models of Care across 17 Middle East and North Africa Countries: Insights into Guidelines, Infrastructure, and Referral Systems Mohamed El-Kassas, Khalid M. AlNaamani, Rofida Khalifa, Yusuf Yilmaz, Asma Labidi, Maen Almattooq, Faisal M. Sanai, Maisam W.I. Akroush Nabil Debzi, Mohammed A. Medhat, Imam Waked, Ali Tumi, Mohamed Elbadry, Mohammed Omer Mohammed, Ala I. Sharara, Ali El Houni, Mohamed Alsenbesy, Hisham El-Khayat, Mina Tharwat, Abdel-Naser Elzouki, Khalid A. Alswat, Zobair M. Younossi, on behalf of the Steatotic Liver Disease Study Foundation in Middle East and North Africa (SLMENA) Collaborators Published online: September 1, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00286

Global Trends and Cross-country Inequalities of Acute Hepatitis E in the Elderly, 1990–2021: A Comprehensive Analysis Deliang Huang, Jinyan Jiang, Jinghan Peng, Zhibin Zhu, Yuanyuan Chen, Siyu Zhang, Huiyi Lai, Hong Yu, Qi Zhao, Yanna Wu, Yanping Chen, Jun Chen Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00101

Orphan Nuclear Receptors in Metabolic Dysfunction-associated Steatotic Liver Disease Development Huan Li, Jian Chen, Ziyin Huang, Mingkai Chen Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00019

Adrenomedullin as an Immunomodulator of CD14+MerTK+ Circulating Monocytes in Liver Failure Syndromes Francesca Maria Trovato, Florent Artru, Roosey Sheth, Rima Abdalla, Joseph Wilson, Anna Broderick, John Smith, Stephen Atkinson, Mark J. McPhail Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00074

Integrated Analysis of Serum and Fecal Metabolites Reveals the Role of Bile Acid Metabolism in Drug-induced Liver Injury: Implications for Diagnostic and Prognostic Biomarkers Simiao Yu, Sici Wang, Ping Li, Haocheng Zheng, Jing Jing, Tingting He, Xia Ding, Ruilin Wang Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00073

Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study Xiuding Zhang, Haoda Weng, Qinzhi Deng, Min Deng, Xuwei Wu, Zuxiong Huang, Shourong Liu, Rui Wu, Chunlian Ma, Yao Xu, Jianfeng Zhong, Jie Yang, Yinxia Wu, Huajiang Shen, Feng Ding, Fang Wang, Xuezhen Zhai, Chunxian Peng, Haotang Ren, Jie Jin, Xiangfei Xu, Xiaofei Li, Xiaoting Ye, Guoqing Qian, Shuilin Sun, Xuebing Yao, Haifeng Miao, Qianggu Xiao, Shaoheng Ye, Qing Zhang, Xinyi Xu, Xia Yu, Yue Yu, Yan Lan, Huilan Tu, Xianbin Xu, Xinrong Zhang, Rui Huang, Xiaohan Qian, Qiao Yang, Jifang Sheng, Yu Shi Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00211

ATOX1 Promotes Hepatocellular Carcinoma Carcinogenesis via Activation of the c-Myb/PI3K/AKT Signaling Pathway Qin Ouyang, Siyu Jia, Qianyu Zhu, Yanmeng Li, Huaduan Zi, Sisi Chen, Pingping He, Hengcheng Tang, Yanling Li, Anjian Xu, Bei Zhang, Xiaomin Wang, Xiaojuan Ou, Donghu Zhou, Jian Huang Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2024.00422

Acute Liver Failure with Determinate rather than Indeterminate Etiology Facilitates Therapy and May Avoid Liver Transplantation: A Critical Analysis Rolf Teschke, Axel Eickhoff Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00203

Targeting Glypican-3 for Liver Cancer Therapy: Clinical Applications and Detection Methods Jin Zhang, Rong Li, Xueqin Tan, Chuang Wang Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00099

Complete Resolution of Refractory Ascites and Pleural Effusion with Sustained Improvement in Urinary Sodium Excretion in a Cirrhotic Patient Treated with Empagliflozin Wei Qin, Yunyi Gao, Yuanyuan Zhao, Ning Bian, Weiguang Fan, Wei Wang, Yuan Gao, Zhongjie Hu Published online: August 28, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00172

Autoimmune Hepatitis Associated with Other Autoimmune Diseases: A Critical Review Danzhu Zhao, George Y. Wu Published online: August 27, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00153

Acute Hepatitis E: A Global Problem, a European Vision Javier Guinea-Castanares, Jesus Iturralde-Iriso, Irune Elizondo-Pinillos, Gloria Martinez-Iniesta Published online: August 27, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00331

Clinical Characteristics and Outcomes of Portal Vein Thrombosis in Patients with Porto-sinusoidal Vascular Disease: A Cohort Study Yanglan He, Hui Liu, Yanna Liu, Ying Han, Chunlei Fan, Yanjing Wu, Lingna Lyv, Xueying Liang, Huiguo Ding Published online: August 27, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00093

Arctigenin Prevents Metabolic Dysfunction-associated Steatohepatitis by Inhibiting NLRP3/GSDMD-N Axis in Macrophages Rui Xue, Lu Jiang, Qian-Ren Zhang, Qing-Jing Wang, Rui-Xu Yang, Tian-Yi Ren, Qin Pan, Jian-Gao Fan Published online: August 25, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00141

Impact of Alanine Transaminase Thresholds on Treatment Eligibility of Patients with Chronic Hepatitis B: A Cross-sectional Study of the China Registry of Hepatitis B Hao Wang, Xiaoqian Xu, Shan Shan, Yuemin Nan, Xiaoyuan Xu, Hui Zhuang, Hong You, Jidong Jia, Yuanyuan Kong, China Registry of Hepatitis B (CR-HepB) Group Published online: August 22, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00252

Gut Microbiota: Implications in Pathogenesis and Potential Therapeutic Target in Primary Biliary Cholangitis Ying Nie, Yu Shi, Yida Yang Published online: August 22, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00212

Co-designing Approaches to Sustainable Exercise Care for People with Metabolic Dysfunction-associated Steatotic Liver Disease Shelley E. Keating, Jack de Boer, Georgina Catsoulis, Jonathan G. Stine, Ana Goode, Graeme A. Macdonald, Elizabeth Powell, Ingrid J. Hickman Published online: August 21, 2025 [ Html ] [ PDF Full-text ] [ Citations ] Doi: 10.14218/JCTH.2025.00155